(2-Fluoro-3,4-dimethoxyphenyl)methanol → 2-Fluoro-3,4-dimethoxybenzaldehyde

HRID 274491

Reaction equation

HRID 274491 reaction equation
[F:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>[O-2].[O-2].[Mn+4].C1C=CC=CC=1>[F:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 1

HCID 19838191(2-Fluoro-3,4-dimethoxyphenyl)methanol

Product 1

HCID 6035882-Fluoro-3,4-dimethoxybenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 241BenzeneSolvent

Procedure

3.0 g of 2-fluoro-3,4-dimethoxybenzyl alcohol and 5.0 g of manganese dioxide are heated under reflux for 1 hour together with 50 ml of benzene. The insoluble constituents are subsequently filtered while washing with methylene chloride. The filtrate is evaporated and the residue is recrystallized from methylene chloride/hexane. There is obtained 2-fluoro-3,4-dimethoxybenzaldehyde of m.p. 52°-54°.

Workup

  1. filtrationThe insoluble constituents are subsequently filtered
  2. washwhile washing with methylene chloride
  3. customThe filtrate is evaporated
  4. customthe residue is recrystallized from methylene chloride/hexane

Sources & evidence

ORD record
ord-44d467d8839847ccb746f07fcfc1078d
Source dataset
uspto-grants-1995_02
Patent number
US05389653

Linked notes

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