Thionyl Chloride → 2-(7-Methoxynaphthalen-1-yl)acetyl chloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([OH:16])=O)=[CH:5][CH:4]=1.S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([Cl:19])=[O:16])=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The 7-methoxynaphth-1-ylacetic acid obtained above is dissolved, while warm, in 300 cm3 of chloroform. The mixture is heated to reflux, and then thionyl chloride is added dropwise. The mixture is refluxed for two hours and evaporated to dryness, yielding an oil which crystallises by cooling. The resulting residue is used as such in the following step.
Workup
- dissolutionis dissolved
- temperatureThe mixture is heated
- temperatureto reflux
- temperatureThe mixture is refluxed for two hours
- customevaporated to dryness
- customyielding an oil which
- customcrystallises
- temperatureby cooling
Sources & evidence
- ORD record
- ord-68b8a011210c4d8fbc1f976d53140819
- Source dataset
- uspto-grants-1995_02
- Patent number
- US05389683
Reaction notes
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