Water → Potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

HRID 274878Notes

Reaction equation

HRID 274878 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:21]([O:23]C)=[O:22])=[N:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=2)[N:4]=1.[OH-].[K+:26].O>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][C:12]2[C:13]([C:21]([O-:23])=[O:22])=[N:14][C:15]([N:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=2)[N:6]=1.[K+:26]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 15767146Methyl 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

Product 1

HCID 23710069Potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9.2 g (27.5 mmol) of methyl 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate was dissolved in 30 ml of methanol, and 1.55 g (27.5 mmol) of 10% potassium hydroxide was added thereto. Furthermore, 20 ml of water was added thereto, and the resultant mixture was stirred at room temperature. The reaction liquor was concentrated under reduced pressure, and acetone was added thereto to precipitate a crystal. The crystal thus obtained was separated by filtration and was washed with hexane to obtain an aimed compound.

Workup

  1. concentrationThe reaction liquor was concentrated under reduced pressure, and acetone
  2. additionwas added
  3. customto precipitate a crystal
  4. customThe crystal thus obtained
  5. customwas separated by filtration
  6. washwas washed with hexane

Sources & evidence

ORD record
ord-d93e6d9e801d4e598a53a7bbcc25c9fb
Source dataset
uspto-grants-1995_02
Patent number
US05391537

Reaction notes

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