1-Phenyl-1,3-propanediol → Hydroxypropiophenone

HRID 275252Notes

Reaction equation

HRID 275252 reaction equation
[C:1]1([CH:7]([OH:11])[CH2:8][CH2:9][OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@@H](O)CCO)C=CC=CC=1>CCCCCC.CC(O)C>[C:1]1([C:7](=[O:11])[CH2:8][CH2:9][OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 5720591-Phenyl-1,3-propanediolHCID 6950537(1S)-1-phenylpropane-1,3-diol

Product 1

HCID 569605Hydroxypropiophenone

Reagents, catalysts & solvents 1

HCID 21585144Isopropanol hexaneSolvent

Procedure

Determination of the absolute configuration, optical purity and reaction yield of 1-phenyl-1,3-propanediol or a derivative thereof in the examples was determined by high pressure liquid chromatography (column: Chiral Cell OB, manufactured by Daisel Chemical Co., eluent: hexane/2-propanol (8/2), flow rate: 0.7 ml/min, detection: UV 210 nm). The reaction yield represents the mole percentage of (S)-1-phenyl-1,3-propanediol produced per mole of 1-phenylpropan-3-ol-1-one added as starting material.

Workup

  1. customThe reaction yield

Sources & evidence

ORD record
ord-4ea4684372744d47a2f4a72e51f79258
Source dataset
uspto-grants-1995_02
Patent number
US05393664

Reaction notes

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