1-Bromopropane → 7-Methoxy-3-propyl-2-trifluoromethylbenzimidazole

HRID 275793Notes

Reaction equation

HRID 275793 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[NH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[CH2:16](Br)[CH2:17][CH3:18]>>[CH3:1][O:2][C:3]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:13])[F:14])[N:8]([CH2:16][CH2:17][CH3:18])[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 178488964HCID 178488964, compound

Product 1

HCID 183166377-Methoxy-3-propyl-2-trifluoromethylbenzimidazole

Procedure

Prepared from 4-methoxy-2-trifluoromethylbenzimidazole (2.4 g) and propyl bromide (3.02 ml). Purification by flash chromatography on silica eluting with 15% ethyl acetate in hexane gave the title compound as a white solid (2.03 g).

Workup

  1. customPurification by flash chromatography on silica eluting with 15% ethyl acetate in hexane

Sources & evidence

ORD record
ord-3768b69c0a5644d48eb12c0816af51a4
Source dataset
uspto-grants-2002_03
Patent number
US06353010B1

Reaction notes

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