Methyl 3-chloro-4-hydroxyphenylacetate → 3-Chloro-4-(3'-methyl-4'-isopropoxybenzyloxy) phenylacetic acid

HRID 27602

Reaction equation

HRID 27602 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[CH2:5]Cl.[Cl:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([O:25]C)=[O:24])[CH:18]=[CH:19][C:20]=1[OH:21]>CO>[Cl:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([OH:25])=[O:24])[CH:18]=[CH:19][C:20]=1[O:21][CH2:5][C:4]1[CH:7]=[CH:8][C:9]([O:10][CH:11]([CH3:13])[CH3:12])=[C:2]([CH3:1])[CH:3]=1

Participants

4

Reactant 2

HCID 92625Methyl 3-chloro-4-hydroxyphenylacetateHCID 123479373-Methyl-4-isopropoxybenzyl chloride

Product 1

HCID 123479583-Chloro-4-(3'-methyl-4'-isopropoxybenzyloxy) phenylacetic acidYield 35.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-chloro-4-(3'-methyl-4'-isopropoxybenzyloxy) phenylacetic acid was prepared in 35.2% yield, m.p. 104°-105° C. (methanol) by reaction of 3-methyl-4-isopropoxybenzyl chloride with methyl 3-chloro-4-hydroxyphenylacetate.

Sources & evidence

ORD record
ord-d8e0b81e2c234c8b87680ef0a112eb96
Source dataset
uspto-grants-1980_09
Patent number
US04221919

Linked notes

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