4-Isopropylbenzyl chloride → 3-Chloro-4-(4'-isopropylbenzyloxy) phenylacetic acid
Reaction equation
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[Cl:12][C:13]1[CH:14]=[C:15]([CH2:20][C:21]([O:23]C)=[O:22])[CH:16]=[CH:17][C:18]=1[OH:19]>CO.O>[Cl:12][C:13]1[CH:14]=[C:15]([CH2:20][C:21]([OH:23])=[O:22])[CH:16]=[CH:17][C:18]=1[O:19][CH2:8][C:7]1[CH:10]=[CH:11][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-chloro-4-(4'-isopropylbenzyloxy) phenylacetic acid was prepared in accordance with the procedure designated (f) above by reacting 4-isopropylbenzyl chloride with methyl 3-chloro-4-hydroxyphenylacetate. The resultant product evidenced a melting point of 146.5°-148° C. in a methanol-water 2:1 mixture.