5-Chlorothieno[3,2-b]pyridine-2-sulfonyl chloride → 5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

HRID 2762

Reaction equation

HRID 2762 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[Cl:18][C:19]1[N:24]=[C:23]2[CH:25]=[C:26]([S:28](Cl)(=[O:30])=[O:29])[S:27][C:22]2=[CH:21][CH:20]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:28]([C:26]2[S:27][C:22]3[C:23](=[N:24][C:19]([Cl:18])=[CH:20][CH:21]=3)[CH:25]=2)(=[O:29])=[O:30])[C:4]1=[O:17])#[N:13]

Participants

3

Reactant 2

HCID 220172995-Chlorothieno[3,2-b]pyridine-2-sulfonyl chlorideHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Product 1

HCID 543133655-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Procedure

The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2sulfonyl chloride. The product is obtained as a white solid.

Workup

  1. customThe product is obtained as a white solid

Sources & evidence

ORD record
ord-e0b43900a7e1454399672e06b3cc15d4
Source dataset
uspto-grants-1998_03
Patent number
US05731315

Linked notes

Loading…