HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-3-isothiocyanato-2-methylbenzene → 2-(3-Chloro-2-methylphenylimino)-3-(cyclobutylmethyl)-1,3-thiazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-3-isothiocyanato-2-methylbenzene | HCID 140504 | — |
| Reactant | N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride | HCID 18316353 | — |
| Product | 2-(3-Chloro-2-methylphenylimino)-3-(cyclobutylmethyl)-1,3-thiazolidine | HCID 18316232 | — |
Reaction Steps
2-Hydroxyethylamine was reacted with cyclobutylmethyl bromide according to Method B2a to give N-cyclobutylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 3-chloro-2-methylphenyl isothiocyanate to give 2-(3-chloro-2-methylphenylimino)-3-(cyclobutylmethyl)-1,3-thiazolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06353006B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-5983525318024b46868aa9d474489f11 |
| Source note | uspto-grants-2002_03 |