1-Isothiocyanato-2-methoxy-4-nitrobenzene → 2-(2-Methoxy-4-nitrophenylimino)-3-(cyclohexylmethyl)-1,3-thiazolidine

HRID 276393

Reaction equation

HRID 276393 reaction equation
[Cl-].[CH:2]1([CH2:8][NH2+:9][CH2:10][CH2:11]Cl)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:13][O:14][C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[N:24]=[C:25]=[S:26]>>[CH3:13][O:14][C:15]1[CH:20]=[C:19]([N+:21]([O-:23])=[O:22])[CH:18]=[CH:17][C:16]=1[N:24]=[C:25]1[N:9]([CH2:8][CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[CH2:10][CH2:11][S:26]1

Participants

3

Reactant 2

HCID 6108371-Isothiocyanato-2-methoxy-4-nitrobenzeneHCID 18316318N-cyclohexylmethyl-N-(2-chloroethyl)ammonium chloride

Product 1

HCID 183164442-(2-Methoxy-4-nitrophenylimino)-3-(cyclohexylmethyl)-1,3-thiazolidine

Procedure

2-Hydroxyethylamine was reacted with cyclohexylmethyl bromide according to Method B2a to give N-cyclohexylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclohexylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 2-methoxy4-nitrophenyl isothiocyanate to give 2-(2-methoxy-4-nitrophenylimino)-3-(cyclohexylmethyl)-1,3-thiazolidine.

Sources & evidence

ORD record
ord-5f227c8ca1db498697b70ac65759e324
Source dataset
uspto-grants-2002_03
Patent number
US06353006B1

Linked notes

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