2-Furancarboxylic acid, 5-methyl- → 2-Methyl-N-(5-methylfuran-2-yl)propanamide

HRID 27661

Reaction equation

HRID 27661 reaction equation
C(O[C:6](=[O:14])[NH:7][C:8]1[O:9][C:10]([CH3:13])=[CH:11][CH:12]=1)(C)(C)C.[CH3:15][C:16]1OC(C(O)=O)=C[CH:17]=1>>[C:6]([NH:7][C:8]1[O:9][C:10]([CH3:13])=[CH:11][CH:12]=1)(=[O:14])[CH:16]([CH3:17])[CH3:15]

Participants

3

Reactant 2

HCID 747102-Furancarboxylic acid, 5-methyl-HCID 10726590Carbamic acid, (5-methyl-2-furanyl)-, 1,1-dimethylethyl ester

Product 1

HCID 233416032-Methyl-N-(5-methylfuran-2-yl)propanamide

Procedure

tert-Butyl-5-methyl-2-furylcarbamate, (mp 80° C., 24 g, 0.12 mole) prepared as in Example 1 from 5-methyl-2-furoic acid was reacted as in Example 2 to give 2-isobutanamido-5-methylfuran (13.4 g) mp 78° C. which was then reacted as in Example 4 to give the title compound. b.p. 94° C./0.3 mm.

Workup

  1. customwas reacted as in Example 2

Sources & evidence

ORD record
ord-51537bb11d0b470d8708281fd0fb3012
Source dataset
uspto-grants-1980_09
Patent number
US04222946

Linked notes

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