1-Benzofuran-2-carbohydrazide → Benzofuran-2-carboxylic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide

HRID 277027

Reaction equation

HRID 277027 reaction equation
C(O[C:4](=[NH:15])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])=[O:7])C.[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[C:17]1[C:25]([NH:27][NH2:28])=[O:26]>C(Cl)(Cl)Cl>[NH2:15][C:4](=[N:28][NH:27][C:25]([C:17]1[O:16][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=1)=[O:26])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])=[O:7]

Participants

4

Reactant 2

HCID 4686461-Benzofuran-2-carbohydrazideHCID 700894422-(Phenylsulfonyl)-ethanimidic acid ethyl ester

Product 1

HCID 86757846Benzofuran-2-carboxylic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazideYield 59.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

3.4 g (0.0125 Mol) of 2-(phenylsulfonyl)-ethanimidic acid ethyl ester was stirred together with 2.2 g (0.015 mol) benzofuran-2-carboxylic acid hydrazide in 80 ml chloroform for 24 hours at 50° C. The resulting precipitate was filtered off and dried. 2.67 g of benzofuran-2-carboxylic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide was obtained as off-white crystals. Mp.: 205-220° C.

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. customdried

Sources & evidence

ORD record
ord-90d700d44f77465ebf7f7a966020652e
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Linked notes

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