2-Chloroaniline → 2-(2-(2-Chlorophenylamino)phenyl)acetic acid

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[Cl:12][C:13]1[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=1[NH2:15]>>[Cl:12][C:13]1[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=1[NH:15][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 72402-Chloroaniline

HCID 877542-Bromophenylacetic acid

Product 1

HCID 137525842-(2-(2-Chlorophenylamino)phenyl)acetic acid

Procedure

In the manner described in example 3, 2-bromophenylacetic acid was condensed with 2-chloroaniline to yield 2-[(2-chlorophenyl)amino]phenylacetic acid.

Sources & evidence

ORD record: ord-f00a8032de4948799f68efa46595426c
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06355680B1

Reaction notes

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