5-Chloro-2-methoxyaniline → 2-[(2-Methoxy-5-chlorophenyl)amino]phenylacetic acid

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12][O:13][C:14]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:15]=1[NH2:16]>>[CH3:12][O:13][C:14]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:15]=1[NH:16][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 667635-Chloro-2-methoxyaniline

HCID 877542-Bromophenylacetic acid

Product 1

HCID 185463222-[(2-Methoxy-5-chlorophenyl)amino]phenylacetic acid

Procedure

In the manner described in example 3, 2-bromophenylacetic acid is condensed with 2-methoxy-5-chloroaniline to yield 2-[(2-methoxy-5-chlorophenyl)amino]phenylacetic acid.

Sources & evidence

ORD record: ord-139d5c12a39249bf88a662bda5045b05
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06355680B1

Reaction notes

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