3-Fluoro-4-methylaniline → 2-[(3-Fluoro-4-methylphenyl)amino]phenylacetic acid

HRID 277281

Reaction equation

HRID 277281 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[F:12][C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][C:19]=1[CH3:20])[NH2:16]>>[F:12][C:13]1[CH:14]=[C:15]([NH:16][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[CH2:8][C:9]([OH:11])=[O:10])[CH:17]=[CH:18][C:19]=1[CH3:20]

Participants

3

Reactant 2

HCID 99573-Fluoro-4-methylanilineHCID 877542-Bromophenylacetic acid

Product 1

HCID 185463762-[(3-Fluoro-4-methylphenyl)amino]phenylacetic acid

Procedure

In the manner described in example 3, 2-bromophenylacetic acid is condensed with 3-fluoro-4-methylaniline to yield 2-[(3-fluoro-4-methylphenyl)amino]phenylacetic acid.

Sources & evidence

ORD record
ord-50f45761dcbc4ab080b233c452a81074
Source dataset
uspto-grants-2002_03
Patent number
US06355680B1

Linked notes

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