Methyl vinyl ketone → 5-Nonyn-2-one, 9-chloro-

14.85 Parts of 5-chloropent-1-yne is dissolved in 250 parts by volume of toluene and the resulting solution is cooled to approximately -40°. To that solution is then added 62.8 parts by volume of 2.31 M ethereal butyl lithium and stirring is continued for approximately 15 minutes. 6.87 Parts of boron trifluoride etherate is added and the reaction mixture is stirred for about 2 hours, then allowed to stand for about 16 hours at -5° to -10°. At the end of that time 10.14 parts of methyl vinyl ketone is added at -40° and the reaction mixture is stirred for about 4 hours, then is quenched with water. 50 Parts by volume of 3 N hydrochloric acid is added and the mixture is kept at room temperature for about 16 hours, at the end of which time the aqueous and organic layers are separated. The aqueous layer is extracted with toluene and the organic layer with water. The organic solutions are combined, washed successively with aqueous sodium hydroxide and water, then dried over anhydrous sodium sulfate and stripped to dryness under reduced pressure, thus affording the crude product. This material is purified by distillation under reduced pressure to afford 9-chloro-5-nonyn-2-one, boiling at about 80°-92° at a pressure of 0.11-0.06 mm.

1. temperaturethe resulting solution is cooled to approximately -40°
2. stirringthe reaction mixture is stirred for about 2 hours
3. waitto stand for about 16 hours at -5° to -10°
4. stirringthe reaction mixture is stirred for about 4 hours
5. customis quenched with water
6. addition50 Parts by volume of 3 N hydrochloric acid is added
7. waitthe mixture is kept at room temperature for about 16 hours, at the end of which time
8. customthe aqueous and organic layers are separated
9. extractionThe aqueous layer is extracted with toluene
10. washwashed successively with aqueous sodium hydroxide and water
11. dry with materialdried over anhydrous sodium sulfate
12. customthus affording the crude product
13. distillationThis material is purified by distillation under reduced pressure

ORD record

ord-a6ca3969df8a4cf88b27b5f2f6b8a062

Source dataset

uspto-grants-1980_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04223158