Toluene → 1,3-Bis(methoxymethyl)urea
Reaction equation
CC1(C)CC(CC(N)[C:10]([NH:12]N)=[O:11])CC(C)(C)N1.[CH3:18][O:19][CH2:20][N:21]=[C:22]=[O:23].[C:24]1(C)C=CC=CC=1>>[CH3:18][O:19][CH2:20][NH:21][C:22]([NH:12][CH2:10][O:11][CH3:24])=[O:23]Participants
4
Conditions
- Temperature
- 25 °C
Procedure
36.3 parts of β-(2,2,6,6-tetramethylpiperidin-4-yl)-aminopropionic acid hydrazide were dissolved in 100 parts of toluene, followed by the dropwise addition of 28.2 parts of 93% methoxymethyl isocyanate. After stirring for 1 hour at 25° C., the deposit was filtered off under suction. The filter residue was stirred with 300 parts of petroleum ether and refiltered under suction. 48 parts of colourless crystals melting at 62° to 65° C. were left after drying. C18H36N6O5 (416.5).
Workup
- filtrationthe deposit was filtered off under suction
- stirringThe filter residue was stirred with 300 parts of petroleum ether
- wait48 parts of colourless crystals melting at 62° to 65° C. were left
- customafter drying
Sources & evidence
- ORD record
- ord-bcf0bfb93c914895949d2f975ba466f5
- Source dataset
- uspto-grants-1980_09
- Patent number
- US04223147
Reaction notes
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