2-Amino-3-nitrobenzoic acid → 2,3-Diaminobenzoic acid

HRID 278030

Reaction equation

HRID 278030 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H]>CO.[Pd]>[NH2:1][C:2]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 2196332-Amino-3-nitrobenzoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 1980692,3-Diaminobenzoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

14 g (76.9 mmol) of 2-amino-3-nitrobenzoic acid (1b) were dissolved in 500 ml of methanol, treated with Pd/C, and hydrogenated with hydrogen. After 4 h, the catalyst was filtered off with suction and concentrated. A dark-brown solid was obtained. Yield: 11.67 g (99%).

Workup

  1. filtrationthe catalyst was filtered off with suction
  2. concentrationconcentrated
  3. customA dark-brown solid was obtained

Sources & evidence

ORD record
ord-2b175d8949474a819a64b0b78c04ef77
Source dataset
uspto-grants-2002_03
Patent number
US06358978B1

Linked notes

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