1-Fluoro-4-methoxy-2-vinylbenzene → 2-Ethyl-1-fluoro-4-methoxybenzene
Reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]([O:10][CH3:11])[CH:6]=[CH:7][C:8]=1[F:9])=[CH2:2]>C(O)C.[Pd]>[CH2:1]([C:3]1[CH:4]=[C:5]([O:10][CH3:11])[CH:6]=[CH:7][C:8]=1[F:9])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 9 g of 3-ethenyl-4-fluoroanisole in 200 ml of ethanol was added 0.9 g of palladium/carbon. The resulting mixture was stirred under hydrogen atmosphere overnight, and filtered through Celite. The filtrate was evaporated, and the resulting residue was subjected to silica gel column chromatography (developer: 50% ethyl acetate/n-hexane) to give 7.0 g of the title compound as a colorless oil.
Workup
- filtrationfiltered through Celite
- customThe filtrate was evaporated
Sources & evidence
- ORD record
- ord-62a33c29d8374648932eba48a27d2fd2
- Source dataset
- uspto-grants-2002_03
- Patent number
- US06358995B1
Reaction notes
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