Ethyl bromoacetate → Ethyl [(3-hydroxyphenyl)sulfanyl]acetate

Reaction equation

Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[OH:8][C:9]1[CH:10]=[C:11]([SH:15])[CH:12]=[CH:13][CH:14]=1>>[OH:8][C:9]1[CH:10]=[C:11]([S:15][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 27366133-Hydroxybenzenethiol

Product 1

HCID 57418561Ethyl [(3-hydroxyphenyl)sulfanyl]acetateYield 41%

Procedure

Ethyl [(3-hydroxyphenyl) sulfanyl]acetate was prepared according to the general method as outlined in example 1 (step 1), starting from ethyl bromoacetate (7.95 g, 47.6 mmol) and 3-hydroxythiophenol (7.95 g, 47.6 mmol); 4.21 g yellow oil. Yield 41%; MS: 211.2 (M−H)−

Sources & evidence

ORD record: ord-58e162b430b44505a73d81600a62874d
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358980B1

Reaction notes

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