(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → (RS)-4-(3,4-Dimethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[CH3:16])[CH2:5][C:6]1([OH:12])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[CH2:17]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][CH:31]([CH2:33]Br)[CH2:30][C:29]=2[CH:35]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[CH3:16])[CH2:5][C:6]1([OH:12])[CH2:11][CH2:10][N:9]([CH2:33][CH:31]2[CH2:30][C:29]3[CH:35]=[C:25]([O:24][CH2:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:26]=[CH:27][C:28]=3[O:32]2)[CH2:8][CH2:7]1Participants
3
Procedure
The title compound MS: m/e=458.6 (M+H+) was prepared from 4-(3,4-dimethyl-benzyl)-piperidin-4-ol and 5-benzyloxy-2-(RS)-bromomethyl-2,3-dihydro-benzofuran.
Sources & evidence
- ORD record
- ord-3a915db050874a32b3d564c47f649739
- Source dataset
- uspto-grants-2002_03