HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → (+-)-4-Hydroxymandelic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Phenol | HCID 996 | — |
| Solvent | Water | HCID 962 | — |
| Product | (+-)-4-Hydroxymandelic acid | HCID 328 | — |
Reaction Steps
The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06359172B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-89b113ed39194d25bd2436f24bca2c8a |
| Source note | uspto-grants-2002_03 |