3,5,5-Trimethylhexanoic acid → n-(3,5,5-Trimethylhexanoyl)-2-butyloctylamine

HRID 278534

Reaction equation

HRID 278534 reaction equation
[CH3:1][CH:2]([CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH2:3][C:4]([OH:6])=O.[CH2:12]([CH:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:17][NH2:18])[CH2:13][CH2:14][CH3:15].CC(N)=NCC1C=CC=C(CN)C=1.Cl.Cl>CCCCCCC>[CH3:1][CH:2]([CH2:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH2:3][C:4]([NH:18][CH2:17][CH:16]([CH2:12][CH2:13][CH2:14][CH3:15])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:6]

Participants

5

Reactant 3

HCID 909603,5,5-Trimethylhexanoic acidHCID 27335151400w DihydrochlorideHCID 186732842-Butyl-n-octan-1-amine

Product 1

HCID 18673287n-(3,5,5-Trimethylhexanoyl)-2-butyloctylamineYield 77%

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

29.2 g of 3,5,5-trimethylhexanoic acid and 34.2 g of 2-butyloctylamine were mixed together in an open Pyrex container and placed in a microwave oven (Menumaster™3100 i; frequency 2450, power at a setting of 30%: 1400 W). After 6 irradiations of about 5 minutes (for each irradiation), the reaction mixture was dissolved in heptane and then purified on silica. 46 g (77%) of the desired amide were obtained.

Workup

  1. customplaced in a microwave oven
  2. customAfter 6 irradiations of about 5 minutes (for each irradiation), the reaction mixture
  3. custompurified on silica

Sources & evidence

ORD record
ord-5fb2aa7435834a2a9de928fec37e62b3
Source dataset
uspto-grants-2002_03
Patent number
US06359175B1

Linked notes

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