Sodium Hydroxide → 2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid
Reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[O:18][C:17]([CH3:23])([CH3:22])[CH2:16][C:15]3([CH3:25])[CH3:24])=[CH:6][C:5]=1[F:26].[OH-].[Na+]>CO>[F:26][C:5]1[CH:6]=[C:7]([C:10]#[C:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[O:18][C:17]([CH3:23])([CH3:22])[CH2:16][C:15]3([CH3:25])[CH3:24])[CH:8]=[CH:9][C:4]=1[C:3]([OH:27])=[O:2]Participants
4
Procedure
Following general procedure L and using 2-fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid methyl ester (Compound 29, 0.14 g, 0.4 mmol), 5 mL of methanol and 1M sodium hydroxide solution (2 mL) followed by recrystallization from ethyl acetate, the title compound was obtained (0.083 g, 58%).