Butanenitrile, 3-imino- → 1-(6-chloropyridazin-3-yl)-3-methyl-1H-pyrazol-5-amine

HRID 27893

Reaction equation

HRID 27893 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:8][NH2:9])=[CH:6][CH:7]=1.N=[C:11]([CH3:15])[CH2:12][C:13]#[N:14]>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:13]([NH2:14])=[CH:12][C:11]([CH3:15])=[N:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 70698Butanenitrile, 3-imino-HCID 1007873-Chloro-6-hydrazinopyridazine

Product 1

HCID 64088451-(6-chloropyridazin-3-yl)-3-methyl-1H-pyrazol-5-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 14.5 g (0.1 moles) of 3-chloro-6-pyridazinyl-hydrazine, 8.5 g (0.1 moles) of 3-iminobutyronitrile and 150 ml of ethanol is heated to reflux for 9 hours. After cooling the separated crystals are filtered, washed with ethanol and dried. Yield: 15.6 g (74.0%); m.p.: 148°-150° C. The hydrochloride melts at 157°-159° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 9 hours
  3. temperatureAfter cooling the separated crystals
  4. filtrationare filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-f95930bf92b241b29b08fdf04c19328f
Source dataset
uspto-grants-1980_09
Patent number
US04224325

Linked notes

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