1-Indanone → 3-Bromo-1-indanone

HRID 279152

Reaction equation

HRID 279152 reaction equation
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C1C(=O)N([Br:18])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:18][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1](=[O:10])[CH2:2]1

Participants

4

Reactant 2

HCID 67351-IndanoneHCID 67184N-bromobutanimide

Product 1

HCID 117459123-Bromo-1-indanone

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

1-Indanone (1 g) and NBS (1.4 g) was mixed with dry CCl4 (20 ml). A catalytic amount of AlBN was added and the mixture was refluxed for 30 minutes and excited with light using 250 W lamp. The mixture was cooled in an ice bath and filtered. The filtrate was concentrated in an evaporator and used without further purification for the next step. Yield was 1.5 g.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureThe mixture was cooled in an ice bath
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated in an evaporator
  5. customused without further purification for the next step

Sources & evidence

ORD record
ord-c54a0fd89f4a4e89ae60c4b36eb93b67
Source dataset
uspto-grants-2002_03
Patent number
US06362211B1

Linked notes

Loading…