Ethanol → alpha-p-cyclohexylphenyl-N-p-chlorophenylnitrone

HRID 27918

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][OH:9])=[CH:4][CH:3]=1.[CH:10]1([C:16]2[CH:23]=[CH:22][C:19](C=O)=[CH:18][CH:17]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.[CH2:24](O)C>>[CH2:19]1[CH2:18][CH2:17][CH:16]([C:10]([C:15]2[CH:24]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[N+:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[O-:9])[CH2:23][CH2:22]1

Participants

Reactant 3

HCID 702Ethanol

HCID 699834-Chlorophenylhydroxylamine

HCID 119689p-Cyclohexylbenzaldehyde

Product 1

HCID 86736527alpha-p-cyclohexylphenyl-N-p-chlorophenylnitrone

Procedure

p-Chlorophenylhydroxylamine (0.05 moles) was dissolved in warm 95% ethanol (40 cc) and was treated with p-cyclohexylbenzaldehyde (0.05 moles) with vigorous stirring. The solid which formed was collected, washed with 95% ethanol, and was recrystallized from ethanol to give α-p-cyclohexylphenyl-N-p-chlorophenylnitrone.

Workup

customThe solid which formed
customwas collected
washwashed with 95% ethanol
customwas recrystallized from ethanol

Sources & evidence

ORD record: ord-a08ba00d67694fe28cd804ece3bd15f7
Source dataset: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04224340

Linked notes

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