Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

Reaction equation

Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

Participants

Reactant 4

HCID 1032Propionic Acid

HCID 6578Propionamide

HCID 14798Sodium Hydroxide

HCID 743283-Chloro-2,4-pentanedione

Product 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

Procedure

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.