HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylcyclohexanone → Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylcyclohexanone | HCID 11525 | — |
| Reactant | L-Cysteine, methyl ester, hydrochloride | HCID 2733208 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride | HCID 86740772 | — |
Reaction Steps
34.3 g of L-cysteine methyl ester hydrochloride and 15.4 ml of 4-methylcyclohexanone are suspended in 70 ml of methanol and the suspension is refluxed for 3 hours. The suspension is concentrated to dryness under reduced pressure and the residue is recrystallized from isopropanol/methanol to give 25 g of colorless crystals of melting point 180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587250 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-8dfe6a8dff9f400ebc720d0b424d8c3a |
| Source note | uspto-grants-1986_05 |