Ammonia → D-Ribopyranosyl amine

HRID 279925

Reaction equation

HRID 279925 reaction equation
O=[CH:2][C@@H:3]([C@@H:5]([C@@H:7]([CH2:9][OH:10])[OH:8])[OH:6])[OH:4].[Cl-].[NH4+:12].N>CO>[CH:9]1([NH2:12])[O:10][CH2:2][C@@H:3]([OH:4])[C@@H:5]([OH:6])[C@H:7]1[OH:8]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 5311110Aldehydo-D-ribose

Product 1

HCID 54279899D-Ribopyranosyl amineYield 932.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 100 ml of methanol was added 20 g of D-ribose and 0.5 g of ammonium chloride. This mixture was treated with anhydrous ammonia at 0° C. until a solution was obtained. This solution was stored at 0° C. for 13 days, then the solid was collected, giving 13 g of D-ribopyranosylamine.

Workup

  1. customwas obtained
  2. customthe solid was collected

Sources & evidence

ORD record
ord-6c82f99df2f64048a4c2ef165cd553e6
Source dataset
uspto-grants-1986_05
Patent number
US04587331

Linked notes

Loading…