Methanol → D-Tyrosine

HRID 280507

Reaction equation

HRID 280507 reaction equation
[NH2:1][C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.CO.O>C(#N)C>[NH2:1][C@@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 962WaterHCID 6057L-Tyrosine2×

Product 1

HCID 71098D-Tyrosine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Example 1 was repeated with the difference that the sample to be tested was a tyrosine of unknown enantiomer composition, the comparison samples were (RS)-, (R)-, and (S)-tyrosine, and the mobile phase was a mixture of methanol, water, and acetonitrile in a 1:1:0.6 ratio by volume. In this case, the (R)-tyrosine gave a spot with an Rf -value of 0.34 and the (S)-tyrosine gave a spot with an Rf value of 0.26.

Sources & evidence

ORD record
ord-b797c9bf619347f691fe461e33ed48fa
Source dataset
uspto-grants-1986_05
Patent number
US04590167

Linked notes

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