Ammonia → Cyromazine

HRID 28111

Reaction equation

HRID 28111 reaction equation
[CH:1]1([NH:4][C:5]2[N:10]=[C:9](Cl)[N:8]=[C:7]([NH2:12])[N:6]=2)[CH2:3][CH2:2]1.[NH3:13]>O1CCOCC1>[CH:1]1([NH:4][C:5]2[N:10]=[C:9]([NH2:13])[N:8]=[C:7]([NH2:12])[N:6]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 233389806-Chloro-N~2~-cyclopropyl-1,3,5-triazine-2,4-diamine

Product 1

HCID 47866CyromazineYield 55.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
140 °C

Procedure

A mixture of 100 g of 2-cyclopropylamino-4-chloro-6-amino-s-triazine, 51 g of anhydrous ammonia and 500 ml of dioxane is heated for 24 hours in an autoclave at 140° C. After cooling to room temperature the solvent is removed by water jet vacuum distillation. 300 ml of water are added to the residue. After stirring, the residue product is filtered off and recrystallised from boiling ethanol. 50 g of 2-cyclopropylamino-4,6-diamino-s-triazine are obtained. Melting point: 219°-222° C.

Workup

  1. temperatureAfter cooling to room temperature the solvent
  2. customis removed by water jet vacuum distillation
  3. addition300 ml of water are added to the residue
  4. filtrationthe residue product is filtered off
  5. customrecrystallised

Sources & evidence

ORD record
ord-1ea168a6fd874ae1beb21deef9846912
Source dataset
uspto-grants-1980_09
Patent number
US04225598

Linked notes

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