3-Bromo-1-methyl-1,2-dihydropyridin-2-one → 8-(1-Methyl-2-oxo-3-pyridinyl)-2-[4-(1,1,1-trifluoropropan-2-yloxy)phenyl]-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[Br:25][c:26]1[c:27](=[O:33])[n:28]([CH3:32])[cH:29][cH:30][cH:31]1.[F:1][C:2]([CH:3]([O:4][c:5]1[cH:6][cH:7][c:8]([N:11]2[C:12](=[O:21])[C:13]3([CH2:14][CH2:15]2)[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:9][cH:10]1)[CH3:22])([F:23])[F:24]>>[F:1][C:2]([CH:3]([O:4][c:5]1[cH:6][cH:7][c:8]([N:11]2[C:12](=[O:21])[C:13]3([CH2:14][CH2:15]2)[CH2:16][CH2:17][N:18]([c:26]2[c:27](=[O:33])[n:28]([CH3:32])[cH:29][cH:30][cH:31]2)[CH2:19][CH2:20]3)[cH:9][cH:10]1)[CH3:22])([F:23])[F:24]Participants
3
Sources & evidence
- ORD record
- ord-367be13748bc4f4597e1e5b8d8719dfd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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