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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 283045Generated: October 25, 2026

4-Hydroxy-2-hydroxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester → 4-[4-(Azetidine-1-carbonyl)-3-fluoro-phenoxy]-2-hydroxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/283045

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Hydroxy-2-hydroxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl esterHCID 59559905—
ReactantAzetidin-1-yl-(2,4-difluorophenyl)methanoneHCID 59560289—
Reactant6-(4-Methanesulfonyl-phenoxy)-2-methyl-2,3-dihydro-benzofuran-4-carboxylic acid methyl esterHCID 59560437—
Product4-[4-(Azetidine-1-carbonyl)-3-fluoro-phenoxy]-2-hydroxymethyl-2-methyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl esterHCID 59559949—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-bfc5a951187e4fdd90557e21af573d9f
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)