HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Diketene acetone | HCID 87118046 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(1,3-Dioxobutyl)pyrrolidine | HCID 100722 | 97.9% |
Reaction Steps
9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731322 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-fc50405695d1443a80eda06a3dd99d45 |
| Source note | uspto-grants-1998_03 |