Ammonia → 8-(2-aminoethyl)-7-isopropyl-1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridin-8-ol

Reaction equation

[CH2:20]([OH:21])[CH3:22].[CH3:24][CH2:25][OH:26].[Co:27].[NH3:23].[OH:1][C:2]1([CH2:17][C:18]#[N:19])[CH:3]([CH:14]([CH3:15])[CH3:16])[CH2:4][c:5]2[c:6]1[c:7]1[c:8]([n:9][cH:10]2)[O:11][CH2:12][CH2:13]1>>[OH:1][C:2]1([CH2:17][CH2:18][NH2:19])[CH:3]([CH:14]([CH3:15])[CH3:16])[CH2:4][c:5]2[c:6]1[c:7]1[c:8]([n:9][cH:10]2)[O:11][CH2:12][CH2:13]1

Participants

Reactant 4

HCID 222Ammonia

HCID 702Ethanol2×

HCID 104730Cobalt

HCID 59179402(8-hydroxy-7-isopropyl-1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridin-8-yl)acetonitrile

Product 1

HCID 591793768-(2-aminoethyl)-7-isopropyl-1,6,7,8-tetrahydro-2H-cyclopenta[d]furo[2,3-b]pyridin-8-ol

Sources & evidence

ORD record: ord-49588caaffb74bfd98a87ed6d3e31f02
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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