HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → Dimethylacetoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Diketene acetone | HCID 87118046 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Dimethylacetoacetamide | HCID 16278 | — |
Reaction Steps
A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731322 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-eb592b1203c74e969732293b7513ee02 |
| Source note | uspto-grants-1998_03 |