Sodium Hydroxide → HCID 178418387, compound
Reaction equation
[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[CH2:4][C:5](=[O:7])[CH3:6].[OH-].[Na+].[Cl-].[C:13]1([N+:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[C:4](=[N:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:5](=[O:7])[CH3:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
4.5 g (0.035 mol) of N,N-dimethyl-3-oxobutyramide, a solution of 4.9 g (0.122 mol) of NaOH in 45 ml of water and 0.037 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 0%→100%) obtaining 3.5 g of the title compound which was used as such in the subsequent step. M.p.=131°-133° C.
Workup
- customas described in preparation 8
- customThe crude reaction mixture
- customwas purified by chromatography on silica gel (hexane/Et2O 0%→100%)
Sources & evidence
- ORD record
- ord-b070703fd73b4d8680fe6f71c91c67d7
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05731322
Reaction notes
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