HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine | HCID 238748 | 60% |
Reaction Steps
A mixture of 4,6-dichloro-pyrimidin-2-yl-amine (3.3 g, 20 mmol), p-tolylamine (3.4 g, 32 mmol) and N,N-diisopropylethylamine (12 ml) in ethanol (150 ml) was heated under reflux for 40 hours. After cooling to room temperature, filtration provided 6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine (2.8 g, 60% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419984B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-4b58f671d02747c482395d81bde4e44d |
| Source note | uspto-grants-2008_09 |