Sodium Hydroxide → HCID 178418482, compound
Reaction equation
[O:1]=[C:2]([CH3:7])[CH2:3][C:4]([NH2:6])=[O:5].[OH-].[Na+].[Cl-].[C:11]1([N+:17]#[N:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[C:11]1([NH:17][N:18]=[C:3]([C:2](=[O:1])[CH3:7])[C:4]([NH2:6])=[O:5])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5.0 g (0.049 mol) of 3-oxobutyramide, a solution of 6.9 g (0.171 mol) of NaOH in 75 ml of water and 0.051 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which was used as such in the subsequent step. M.p.=146°-147° C.
Workup
- customas described in preparation 8
- customThe crude reaction mixture
- customwas purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which
Sources & evidence
- ORD record
- ord-fa496a7ce126439c8a04c703ffcedc08
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05731322
Reaction notes
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