HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178418328, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzenediazonium chloride | HCID 60992 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Reactant | HCID 178418247 | HCID 178418247 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178418328 | HCID 178418328 | 60% |
Reaction Steps
7.3 ml (0.05 mol) of ethyl 3-oxo-4,4,4-trifluoroacetoacetate, 6 g (0.073 mol) of CH3COONa, 20 ml of water, 37.5 ml of ethanol and a solution of 0.05 mol of phenyldiazonium chloride were treated as described in preparation 2. The crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%) obtaining 8.65 g of the title compound. M.p.=78°-80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731322 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-5378909b6f194efbaaaae9d5077f9d43 |
| Source note | uspto-grants-1998_03 |