HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine → 4-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine | HCID 86004374 | — |
| Reactant | 2-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol | HCID 136080012 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | 4-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine | HCID 86004380 | 42% |
Reaction Steps
Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-methoxy-ethanol provided 4-[5-bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine (42% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419984B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-999ac6a17c854f6d814498b7c611ec8a |
| Source note | uspto-grants-2008_09 |