4-Chloroaniline → 6-(2-Benzyloxy-5-chloro-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

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Reaction Steps

Following the method described in Example 72, 4-(2-benzyloxy-5-chloro-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-chloro-aniline provided the title compound (98% yield). 1H NMR (CD3OD) δ 5.26 (s, 2H, CH2), 6.44 (s, 1H, Ar), 7.21 (d, 1H, J=8.8 Hz, Ar), 7.33-7.36 (m, 2H, Ar), 7.38-7.43 (m, 4H, Ar), 7.45 (d, 1H, J=8.8 Hz, Ar), 7.58-7.61 (m, 2H, Ar), 7.80-7.82 (m, 2H, Ar).

Provenance & Evidence