Cyclohexane, (bromomethyl)- → 4-Chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine

HRID 28652Notes

Reaction equation

HRID 28652 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[OH:15])[CH:5]=[C:4]([Cl:16])[N:3]=1.Br[CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[Cl:16][C:4]1[CH:5]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:7]=[C:2]([NH2:1])[N:3]=1

Participants

3

Reactant 2

HCID 137636Cyclohexane, (bromomethyl)-HCID 1363418892-(2-Amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol

Product 1

HCID 860043894-Chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamineYield 20%

Procedure

Following the method described in Example 72, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol and bromomethyl-cyclohexane provided 4-chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine (20% yield).

Sources & evidence

ORD record
ord-778cf8719f8249e19044b040f9b929ea
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Reaction notes

Loading…