6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-amine → HCID 11293618, compound

HRID 28716

Reaction equation

HRID 28716 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9](Cl)(=[O:11])=[O:10].[Br:13][C:14]1[CH:15]=[C:16]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]1[CH:21]([NH2:27])[CH2:20][CH2:19][CH2:18][C:17]2=1>>[Br:13][C:14]1[CH:15]=[C:16]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]1[CH:21]([NH:27][S:9]([C:3]3[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=3[F:8])(=[O:11])=[O:10])[CH2:20][CH2:19][CH2:18][C:17]2=1

Participants

3

Reactant 2

HCID 5978796-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-amineHCID 27342712,6-Difluorobenzenesulfonyl chloride

Product 1

HCID 11293618HCID 11293618, compound

Procedure

N-(6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-2,6-difluorobenzenesulfonamide was prepared from 2,6-difluorobenzenesulfonylchloride and 6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-amine in a similar manner as described above to give a white solid: 1H-NMR (CDCl3): δ 8.60 (s, 1H), 7.48-7.58 (m, 2H), 7.24 (dd, 1H), 7.18 (d, 1H), 7.04 (t, 1H), 5.31 (m, 1H), 4.73 (m, 1H), 2.62 (m, 2H), 1.7-2.1 (m, 4H).

Workup

  1. customto give a white solid

Sources & evidence

ORD record
ord-99a35d8db96b4e6f97f5a001a279a338
Source dataset
uspto-grants-2008_09
Patent number
US07419997B2

Linked notes

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