Dichloromethane → 2-Cyclopropyl-1-{4-[6-fluoro-2-phenoxymethyl-3-(4-trifluoromethoxy-benzyl)-3H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanone

HRID 290987

Reaction equation

HRID 290987 reaction equation
[CH:1]1([CH2:4][C:5](=[O:6])[OH:7])[CH2:2][CH2:3]1.[Cl:44][CH2:45][Cl:46].[F:8][c:9]1[cH:10][c:11]2[c:12]([n:13]([CH2:24][c:25]3[cH:26][cH:27][c:28]([O:31][C:32]([F:33])([F:34])[F:35])[cH:29][cH:30]3)[c:14]([CH2:16][O:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[n:15]2)[cH:36][c:37]1[N:38]1[CH2:39][CH2:40][NH:41][CH2:42][CH2:43]1>>[CH:1]1([CH2:4][C:5](=[O:7])[N:41]2[CH2:40][CH2:39][N:38]([c:37]3[c:9]([F:8])[cH:10][c:11]4[c:12]([n:13]([CH2:24][c:25]5[cH:26][cH:27][c:28]([O:31][C:32]([F:33])([F:34])[F:35])[cH:29][cH:30]5)[c:14]([CH2:16][O:17][c:18]5[cH:19][cH:20][cH:21][cH:22][cH:23]5)[n:15]4)[cH:36]3)[CH2:43][CH2:42]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 138440Cyclopropaneacetic acidHCID 684671025-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole

Product 1

HCID 684635972-Cyclopropyl-1-{4-[6-fluoro-2-phenoxymethyl-3-(4-trifluoromethoxy-benzyl)-3H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanone

Sources & evidence

ORD record
ord-cef28b487bc54a6b94418f8e1955a4dc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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