1,4-Dibromo-2-butanol → N-[(1RS,2SR)-2-(3-Hydroxy-pyrrolidin-1-yl)-cyclopentyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 291178

Reaction equation

HRID 291178 reaction equation
[Br:24][CH2:25][CH:26]([CH2:27][CH2:28][Br:29])[OH:30].[NH2:1][CH:2]1[CH:3]([NH:7][C:8]([c:9]2[c:10]([O:21][CH3:22])[cH:11][c:12]([C:17]([F:18])([F:19])[F:20])[cH:13][c:14]2[S:15][CH3:16])=[O:23])[CH2:4][CH2:5][CH2:6]1>>[N:1]1([CH:2]2[CH:3]([NH:7][C:8]([c:9]3[c:10]([O:21][CH3:22])[cH:11][c:12]([C:17]([F:18])([F:19])[F:20])[cH:13][c:14]3[S:15][CH3:16])=[O:23])[CH2:4][CH2:5][CH2:6]2)[CH2:25][CH:26]([OH:30])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 295701,4-Dibromo-2-butanolHCID 66681196N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Product 1

HCID 66682712N-[(1RS,2SR)-2-(3-Hydroxy-pyrrolidin-1-yl)-cyclopentyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-5b6aff62e1844e149f9df0a7852f94d2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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