Methyl Acetate → {3-[2-(2,4-Dichloro-benzoyl)3-methyl-benzofuran-6-yl]-phenyl}-acetic acid methyl ester
Reaction equation
Br[C:2]1[CH:21]=[CH:20][C:5]2[C:6]([CH3:19])=[C:7]([C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=3[Cl:18])=[O:10])[O:8][C:4]=2[CH:3]=1.[CH3:22][O:23][C:24](=[O:26])[CH3:25]>>[CH3:22][O:23][C:24](=[O:26])[CH2:25][C:2]1[CH:21]=[CH:20][CH:5]=[C:4]([C:2]2[CH:21]=[CH:20][C:5]3[C:6]([CH3:19])=[C:7]([C:9](=[O:10])[C:11]4[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=4[Cl:18])[O:8][C:4]=3[CH:3]=2)[CH:3]=1Participants
3
Procedure
{3-[2-(2,4-Dichloro-benzoyl)-3-methyl-benzofuran-6-yl]-phenyl}-acetic acid methyl ester was prepared via a Suzuki coupling of (6-Bromo-3-methyl-benzofuran-2-yl)-(2,4-dichloro-phenyl)-methanone and 3-Bromo-phenyl)-acetic acid methyl ester as described in method 1 step 5. MS ES (MH+)453.1, RT=4.27 min).
Sources & evidence
- ORD record
- ord-a588b0422ee0410ab0ab9e31a6bd2112
- Source dataset
- uspto-grants-2008_09