HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propane-2-sulfonamide → 3-Methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propane-2-sulfonamide | HCID 3549191 | — |
| Reactant | 3-Methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester | HCID 86599026 | — |
| Product | 3-Methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester | HCID 68713474 | 23% |
Reaction Steps
Coupling of isopropylsulfonamide with 3-methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester was carried out according to Example 36, Step 1 to give 3-methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester in 23% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.4 (t, J=6.4 Hz, 9 H) 2.9 (t, 3 H) 3.5 (m, 1 H) 4.5 (q, J=7.1 Hz, 2 H) 6.6 (s, 1 H) 7.4 (m, 3 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07420001B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-b95a7ebe74064e24a5a8ee037cf564da |
| Source note | uspto-grants-2008_09 |