6-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one → tert-Butyl 4-{4-[3-(2-fluorophenoxy)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

HRID 293885

Reaction equation

HRID 293885 reaction equation
[Cl:33][CH2:34][c:35]1[cH:36][cH:37][c:38]2[c:39]([cH:50]1)[N:40]([CH2:45][CH2:46][CH2:47][O:48][CH3:49])[C:41](=[O:44])[CH2:42][O:43]2.[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([OH:28])[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:29][cH:30][cH:31][cH:32]1>>[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:28][CH2:34][c:35]4[cH:36][cH:37][c:38]5[c:39]([cH:50]4)[N:40]([CH2:45][CH2:46][CH2:47][O:48][CH3:49])[C:41](=[O:44])[CH2:42][O:43]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:29][cH:30][cH:31][cH:32]1

Participants

3

Reactant 2

HCID 468352236-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68501698tert-Butyl 4-{4-[3-(2-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 68499111tert-Butyl 4-{4-[3-(2-fluorophenoxy)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-726c477782654ed9a89cad1bb6474208
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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